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KMID : 0366119750030020069
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Korean Journal of Applied Microbiology & Bioengineering
1975 Volume.3 No. 2 p.69 ~ p.72
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Studies on the Biological Active Substance Produced by a Strain of Streptomyces sp
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Abstract
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Isolation of the toxic substance which was produced by Streptomyces sp. and it´s biochemical characterestics and toxicity to fishes were reported in the previous paper. The present report includes antibiotic activity of the substance, inhibitory activity of the substance on the succinic dehydrogenase of fishes, and its effect on the blood corpuscles of a rabbit, An evident antibiotic activity of this substance was obssrved on Candida yeasts, but not on molds or bacteria. The substance inhibited the growth of Candida japonica and d. utilis to the 50% at the concentrations of 7.5 and 10.2μg per ml, respectively. The activity of succinic dehydrogenase obtained from various organs of Cyprinous carpio L. was also found to be inhibited by this substance. Original activities of the enzymes from the brain, kidney, and liver, were inhibited by 75.4%, 38.2%, and 26.2%, respectively, but not the enzymes from the heart- and spleen. Neither leukopenia nor leukocytosis was detected after the intravenous administration of the substance to the rabbit at the level of 6 mg per 2 kg body weight.
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